2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. DNA Alkylator/Crosslinker

DNA Alkylator/Crosslinker

DNA Alkylator/Crosslinker

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DNA alkylator/crosslinker is a molecule that alkylates DNA or can cross link with DNA. DNA alkylator/crosslinker can have mutagenic, pharmaceutical, or other effects. Alkylation is the transfer of an alkyl group from one molecule to another. The alkyl group may be transferred as an alkyl carbocation, a free radical, a carbanion or a carbene. Alkylating agents are widely used in chemistry because the alkyl group is probably the most common group encountered in organic molecules. Selective alkylation, or adding parts to the chain with the desired functional groups, is used, especially if there is no commonly available biological precursor. Alkylation with only one carbon is termed methylation. In medicine, alkylation of DNA is used in chemotherapy to damage the DNA of cancer cells. Alkylation is accomplished with the class of drugs called alkylating antineoplastic agents. Crosslinking of DNA occurs when various exogenous or endogenous agents react with two different positions in the DNA. This can either occur in the same strand (intrastrand crosslink) or in the opposite strands of the DNA (interstrand crosslink). Crosslinks also occur between DNA and protein. DNA replication is blocked by crosslinks, which causes replication arrest and cell death if the crosslink is not repaired. The RAD51 family plays a role in repair.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-139621
    Colibactin 742
    		Inducer
    Colibactin 742, a stable colibactin derivative, induces DNA interstrand-cross-links, activation of the Fanconi Anemia DNA repair pathway, and G2/M arrest.
    Colibactin 742
  • HY-105890
    Spiroplatin
    Spiroplatin is a Cisplatin (HY-17394) congener and has antitumor activity.
    Spiroplatin
  • HY-13733R
    Procarbazine (Hydrochloride) (Standard)
    Procarbazine (Hydrochloride) (Standard) is the analytical standard of Procarbazine (Hydrochloride). This product is intended for research and analytical applications. Procarbazine Hydrochloride is an orally active alkylating agent, with anticancer activity. Procarbazine Hydrochloride can be used in Hodgkin's disease research.
    Procarbazine (Hydrochloride) (Standard)
  • HY-B0077S1
    Bendamustine-d8 hydrochloride
    Bendamustine-d8 (hydrochloride) is deuterium labeled Bendamustine (hydrochloride). Bendamustine hydrochloride (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties[1].
    Bendamustine-d<sub>8</sub> hydrochloride
  • HY-16293S
    Lurbinectedin-d3
    Lurbinectedin-d3 is deuterium labeled Lurbinectedin. Lurbinectedin (PM01183) is a DNA minor groove covalent binder with potent anti-tumour activity; inhibits RMG1 and RMG2 cell growth with IC50 values of 1.25 and 1.16 nM, respectively[1].
    Lurbinectedin-d<sub>3</sub>
  • HY-133590
    Heliotrine N-oxide
    Heliotrine N-oxide is the corresponding PA (pyrrolizidine alkaloid) N-oxide of Heliotrine (HY-126128). Heliotrine N-oxide leads to the formation of pyrrolic DNA adducts and potential initiation of PA-induced liver tumors in vivo.
    Heliotrine N-oxide
  • HY-148091
    Duocarmycin analog-2
    Duocarmycin analog-2 is a potent DNA alkylating agent. Duocarmycin analog-2 can be used of synthetic immunoconjugate. Duocarmycin analog-2 has antitumor activity.
    Duocarmycin analog-2
  • HY-106588
    Heptaplatin
    Heptaplatin (SKI 2053R) is a platinum derivative with anticancer activity against various cancer cell lines, including cisplatin-resistant tumor cell lines. SKI-2053R is active in the research of gastric adenocarcinoma and has favorable toxicity profiles.
    Heptaplatin
  • HY-19412
    DMS-612
    DMS-612 (NSC-281612) is an alkylating agent with anti-renal cell carcinoma activity. DMS-612 can be used in cancer research.
    DMS-612
  • HY-13585R
    Carmustine (Standard)
    Carmustine (Standard) is the analytical standard of Carmustine. This product is intended for research and analytical applications. Carmustine is an antitumor chemotherapeutic agent, which works by akylating DNA and RNA.
    Carmustine (Standard)
  • HY-160915
    WP836
    WP836 is a potent antitumor agent. WP836 shows cytoxicity.
    WP836
  • HY-13593S
    Chlorambucil-d8
    Chlorambucil-d8 is the deuterium labeled Chlorambucil. Chlorambucil (CB-1348), an orally active antineoplastic agent, is a bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin’s disease[1][2][3][4].
    Chlorambucil-d<sub>8</sub>
  • HY-137316AR
    Phosphoramide mustard (cyclohexanamine) (Standard)
    Phosphoramide mustard (cyclohexanamine) (Standard)
  • HY-122493
    Illudin M
    		99.53%
    Illudin M is a cytotoxic fungal sesquiterpene that can be isolated from the culture medium of Omphalotus illudens mushrooms. Illudin M can alkylate DNA. Illudin M has anti-tumor activities.
    Illudin M
  • HY-160064
    SW1-A aptamer sodium
    SW1-A aptamer sodium is an optimized aptamer based on SW1 aptamer (HY-160063) that specifically targets liver cancer SMMC-7721 cells (Kd: 133.73 nM). SW1-A aptamer maintains strong affinity to liver cancer tissues and cells.
    SW1-A aptamer sodium
  • HY-144336
    DNA crosslinker 3 dihydrochloride
    DNA crosslinker 3 (dihydrochloride) (compound 1) is a potent DNA minor groove binder with DNA binding affinity (ΔTm) of 1.4 °C. DNA crosslinker 3 (dihydrochloride) can be used for researching anticancer.
    DNA crosslinker 3 dihydrochloride
  • HY-144337
    DNA crosslinker 4 dihydrochloride
    DNA crosslinker 4 (dihydrochloride) is a potent DNA minor groove binder. DNA crosslinker 4 (dihydrochloride) has certain inhibitory activity against cancer cells NCI-H460, A2780 and MCF-7. DNA crosslinker 4 (dihydrochloride) can be used for researching anticancer.
    DNA crosslinker 4 dihydrochloride
  • HY-144333
    DNA crosslinker 1 dihydrochloride
    DNA crosslinker 1 dihydrochloride (Compound 4) is a potent DNA minor groove binder with DNA binding affinity (ΔTm) of 1.1 °C. DNA crosslinker 1 dihydrochloride can be used for researching anticancer.
    DNA crosslinker 1 dihydrochloride
  • HY-W011425
    NTPO
    NTPO (Nitrilotris methylenephosphonic acid) is a DNA damage inducer, causing genomic DNA damage and fragmentation, activating ATR-mediated cell cycle checkpoints. The DNA damaging effects of NTPO are abrogated by base excision repair (BER) but not nucleotide excision repair (NER).
    NTPO
  • HY-13567S
    Bendamustine-d4
    Bendamustine-d4 is the deuterium labeled Bendamustine. Bendamustine is a DNA cross-linking agent that causes DNA breaks, with alkylating and antimetabolite properties.
    Bendamustine-d<sub>4</sub>
Cat. No. Product Name / Synonyms Application Reactivity